Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2000 Nov 6;192(9):1261–1272. doi: 10.1084/jem.192.9.1261

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

graphic file with name JEM000821.f1a.jpg — The acquisition of endosomal proteins by L. pneumophila vacuoles. Macrophages infected with L. pneumophila for the periods indicated were labeled with antibody specific for LAMP-1 or cathepsin D, then stained with DAPI. (A) At 8 h, L. pneumophila vacuoles rarely colocalized with LAMP-1 or cathepsin D (black arrowheads); after 16 h, many L. pneumophila vacuoles were ringed by LAMP-1 and contained cathepsin D (white arrowheads). The percentage of L. pneumophila vacuoles that contained either LAMP-1 (B) or cathepsin D (C) at the time indicated was scored in three separate experiments, each represented by a different symbol (circles, squares, or diamonds).

graphic file with name JEM000821.f1b.jpg — The acquisition of endosomal proteins by L. pneumophila vacuoles. Macrophages infected with L. pneumophila for the periods indicated were labeled with antibody specific for LAMP-1 or cathepsin D, then stained with DAPI. (A) At 8 h, L. pneumophila vacuoles rarely colocalized with LAMP-1 or cathepsin D (black arrowheads); after 16 h, many L. pneumophila vacuoles were ringed by LAMP-1 and contained cathepsin D (white arrowheads). The percentage of L. pneumophila vacuoles that contained either LAMP-1 (B) or cathepsin D (C) at the time indicated was scored in three separate experiments, each represented by a different symbol (circles, squares, or diamonds).