Figure 2.

Impact of L-selectin shedding on jerkiness of rolling. (A) Velocity profiles of three representative rolling leukocytes measured at 0.1 s intervals in untreated wt mice before (left) and after (right) the blockade of L-selectin shedding. Dotted line, critical rolling velocity. (B) Jerkiness (variability of velocity) of 10 rolling leukocytes over 0.1-s intervals before (left) and after (right) the blockade of L-selectin shedding in wt mice. (C) Jerkiness of 10 rolling leukocytes over 0.1 s intervals in TNF-α–treated wt mice before (left) and after (right) blockade of L-selectin shedding with KD-IX-73-4. (D) Jerkiness of 10 rolling leukocytes before (left) and after (right) the blockade of L-selectin shedding in TNF-α–treated EP^−/− mice. Arrows, values of the data points outside of the panel.