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. 2001 Apr 2;193(7):863–872. doi: 10.1084/jem.193.7.863

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© 2001 The Rockefeller University Press

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L-selectin–mediated arrest on cytokine-stimulated endo-thelium. (A) Bars represent mean (± SEM) increase of adherent leukocytes within 8–10 min after blockade of L-selectin shedding with KD-IX-73-4 in various mouse genotypes, compared with adhesion in the same venule without KD-IX-73-4. Studied number of venules/mice for leukocyte adhesion: wt, 17/7; EP^−/−, 8/4; the remaining groups, 5/2 or higher. For CD18 and LFA-1 blockade, mAbs systemically injected before the blockade of L-selectin shedding in EP^−/− mice. Control, onefold increase of adhesion after vehicle in wt or EP^−/− mice within the same time frame. *Significantly different from all other groups. P < 0.05. (B) Representative video micrographs showing the increase of firmly adhering and transmigrating leukocytes before and 8–10 min after blockade of L-selectin shedding in three different gene-targeted mice.