Table 1.

Cytokine Production by CD25⁺CD4⁺ Tr Cells

Stimuli	Cells	IL-2	IL-4	IL-10	IFN-γ	TGF-β
αCD3/28 + IL-2	CD25+	ND	153	1148	5723	1322
αCD3/28 + IL-2	CD25−	ND	94	840	9773	1225
allogeneic APCs	CD25+	<19	<9	298	527	509
allogeneic APCs	CD25−	99.5	<9	251	5744	637

Purified cells were stimulated as indicated and supernatants were collected after 24 (for IL-2) or 72 h. The amount of cytokine was determined by ELISA. Data represent the average values (pg/ml) of pooled data from four independent experiments. Cytokine production by allogeneic APCs alone has been subtracted.