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. 2001 Apr 16;193(8):905–916. doi: 10.1084/jem.193.8.905

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Immunophenotype of parenchymal microglia and perivascular macrophages in macaques with SIVE. (A) CD11b immunoreactivity on brain macrophages. Immunoreactivity is demonstrated on parenchymal microglia evenly spaced throughout the white matter, and on expansive aggregates of perivascular macrophages and MNGCs typical of SIVE. (B) CD14 immunoreactivity on perivascular macrophages within a SIVE lesion. CD14 is not detected on parenchymal microglia. (C) CD45 immunoreactivity on perivascular macrophages and lymphocytes within an SIVE lesion. CD45 is not detected on parenchymal microglia. (D) Viral envelope protein (gp120) in SIVE. The distribution of SIV-gp120 appears to overlap with the distribution of CD11b⁺CD14⁺CD45⁺ perivascular macrophages (A–C). Data presented here are representative of immunohistochemical studies performed on two to three CNS regions of n = 5 animals with SIVE.