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. 2001 Apr 16;193(8):905–916. doi: 10.1084/jem.193.8.905

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Triple-label confocal microscopy of the brain of an SIV-infected macaque. Images for individual channels (CD11b, green; Glut-1, red; and CD14, blue) are shown on the left and a larger merged image contain all three channels plus the differential interference contrast (DIC) image are shown on the right. Parenchymal microglia (CD11b, green) maintain a reticular network in the white matter of SIV-infected macaques. Perivascular macrophages (CD11b⁺CD14⁺, blue-green) are situated around CNS endothelium (Glut-1, red). Both parenchymal microglia (green) and perivascular macrophages (blue-green) are in contact with CNS endothelium where parenchymal microglia have foot processes on endothelium (arrows) and perivascular macrophages are in contact with and wrap around CNS vessels. Bar, 10 μM.