Table 3.
Assessment of Viral DNA, RNA, and Protein in the CNS As a Function of Time After Infection
| Day 3 | Day 7 | Day 14 | Day 21 | Day 50 | SIVE | |
|---|---|---|---|---|---|---|
| SIV DNA | ||||||
| SIVmac239 | − | +/− | + | + | + | + |
| SIVmac251 | − | +/− | + | + | + | + |
| SIV RNA | ||||||
| SIVmac239 | − | +/− | +/− | − | − | + |
| SIVmac251 | − | +/− | +/− | − | − | + |
| SIV protein | ||||||
| SIVmac239 | − | +/− | +/− | − | − | + |
| SIVmac251 | − | +/− | +/− | − | − | + |
Data presented here are the results of n = 2 animals per data point per viral inoculum. Viral DNA was assessed using PCR for gag. Viral RNA was assessed using in situ hybridization with SIV-specific riboprobes. Viral protein was assessed by immunohistochemistry for SIV-gp120 and SIV-p28. −, not detected; +/−, detected in scattered cells or samples; +, detected in all tissues or samples examined.