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. 2001 Apr 16;193(8):925–934. doi: 10.1084/jem.193.8.925

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Partial correction of anemia using Euk-8, a synthetic SOD/catalase. Transplanted animals were divided into two groups that received either Euk-8 at a dose of 30 mg/kg 3 d/wk, or sham injections on the same schedule. Hematocrit (Hct.) and reticulocyte (Retic.) counts were determined after 8 wk of treatment. There was no effect of drug treatment on the hematocrit of animals that received Sod2 ^+/+ or Sod2 ^+/− fetal liver cells. Recipients of Sod2 ^−/− cells showed a significant increase in hematocrit in response to Euk-8 treatment after 8 wk (*P < 0.001) of therapy, and a corresponding decrease in reticulocyte count (P value not significant).