Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2001 Apr 16;193(8):975–980. doi: 10.1084/jem.193.8.975

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Mechanisms underlying the beneficial effects of targeting donor tissue IP-10 expression. (a) Histology showing acute rejection with extensive mononuclear cell infiltration, vascular injury, and myocyte necrosis in grafts from IP-10^+/+ donors versus almost normal histology in grafts from IP-10^−/− donors (day 7 after transplant). Paraffin sections, hematoxylin; original magnifications: ×300. (b) Immunohistologic detection of IP-10, I-TAC, and Mig in cardiac allografts from IP-10^+/+ but not IP-10^−/− donors (day 7 after transplant). Cryostat sections, hematoxylin; original magnifications: ×450. (c) Immunohistologic analysis showed significant reduction in recruitment of intragraft CD45⁺ cells (all leukocytes), CD4 and CD8 T cell subsets, macrophages, and IL-2R⁺ (CD25⁺) cells in allografts from IP-10^−/− versus IP-10^+/+ donors at day 7 after transplantation. Data (mean ± SD) from counting of 20 consecutive fields/graft and 3 grafts/group. *Significantly reduced cell numbers versus controls (*P < 0.05; **P < 0.01; ***P < 0.005).

Mechanisms underlying the beneficial effects of targeting donor tissue IP-10 expression. (a) Histology showing acute rejection with extensive mononuclear cell infiltration, vascular injury, and myocyte necrosis in grafts from IP-10^+/+ donors versus almost normal histology in grafts from IP-10^−/− donors (day 7 after transplant). Paraffin sections, hematoxylin; original magnifications: ×300. (b) Immunohistologic detection of IP-10, I-TAC, and Mig in cardiac allografts from IP-10^+/+ but not IP-10^−/− donors (day 7 after transplant). Cryostat sections, hematoxylin; original magnifications: ×450. (c) Immunohistologic analysis showed significant reduction in recruitment of intragraft CD45⁺ cells (all leukocytes), CD4 and CD8 T cell subsets, macrophages, and IL-2R⁺ (CD25⁺) cells in allografts from IP-10^−/− versus IP-10^+/+ donors at day 7 after transplantation. Data (mean ± SD) from counting of 20 consecutive fields/graft and 3 grafts/group. *Significantly reduced cell numbers versus controls (*P < 0.05; **P < 0.01; ***P < 0.005).