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. 2001 Apr 16;193(8):975–980. doi: 10.1084/jem.193.8.975

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Effects of lack of donor-derived IP-10 on intragraft events. (a) RNase protection assays of intragraft cytokine, chemokine, and chemokine receptor mRNA expression, comparing grafts from IP-10^+/+ (lanes 1–3) to IP-10^−/− (lanes 4–6) donors at day 7 after transplant. (b) Quantitative analysis of RNase protection assay data, showing the significant depression of intragraft IFN-γ, chemokine, and CC and CXC chemokine receptor mRNA expression in IP-10^−/− versus IP-10^+/+ donor hearts. Data are from three transplants/group, as shown, and experiments were performed twice with comparable findings. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001.

Effects of lack of donor-derived IP-10 on intragraft events. (a) RNase protection assays of intragraft cytokine, chemokine, and chemokine receptor mRNA expression, comparing grafts from IP-10^+/+ (lanes 1–3) to IP-10^−/− (lanes 4–6) donors at day 7 after transplant. (b) Quantitative analysis of RNase protection assay data, showing the significant depression of intragraft IFN-γ, chemokine, and CC and CXC chemokine receptor mRNA expression in IP-10^−/− versus IP-10^+/+ donor hearts. Data are from three transplants/group, as shown, and experiments were performed twice with comparable findings. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001.