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. 2001 Jul 2;194(1):13–28. doi: 10.1084/jem.194.1.13

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Schematic representation of the glomerular filter in wild-type and podocalyxin-deficient mice (adapted from reference 14). For ease of presentation, the mesangial cells that would normally link the capillary loops (disrupting the layer of podocytes) have been left out of the diagram. The lack of interdigitating FPs in the podxl ^−/− mice leads to a lack of filtration slit area. This, along with the decrease in the fenestration of the glomerular capillaries, is thought to lead to a decrease in the potential area for filtration and the anuria that occurs in the podxl ^−/− mice.