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. 2001 Jul 16;194(2):127–134. doi: 10.1084/jem.194.2.127

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Parenchymal entry correlates with the site of extravasation in the thymic cortex. The relationship between early precursors and vascular/perivascular tissues was examined using CD25 staining (black) as a marker of DN precursors and tomato lectin (brown) as a marker of vascular endothelium. The transverse section shown in a includes cortical and medullary regions and is parallel to cortical capillary loops. In b, the plane of sectioning is through the deep cortex perpendicular to the orientation of capillary loops. No correlation between CD25⁺ precursors and vascular tissue is seen in either orientation, indicating that the perivascular sheaths are not conduits for the transcortical migration of early thymocytes and that parenchymal entry occurs deep within the tissue.