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. 2001 Jul 16;194(2):219–226. doi: 10.1084/jem.194.2.219

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The effect of mAbs specific for LFA-1, Mac-1, and α4 integrin on neutrophil rolling, adhesion, and migration in LFA-1^+/+ and ^−/− mice. For LFA-1^+/+ mice, anti–LFA-1 mAb significantly affected all three stages of rolling, adhesion, and emigration and anti-α4 mAb had significant impact on cell rolling and adhesion. Anti–Mac-1 mAb significantly affected the emigration step in LFA-1^+/+ but not LFA-1^−/− mice. In LFA-1^−/− mice, only the α4 mAb significantly affects all three steps of rolling velocity, adhesion, and emigration. Data are reported as mean ± SEM.