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. 2001 Aug 6;194(3):343–354. doi: 10.1084/jem.194.3.343

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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TNF contributes to the protective effects of IL-18. (A) Balb/c mice were injected with the mAbs indicated before infection with 2 × 10³ CFU Listeria and the bacterial burden per spleen was evaluated after 2 or 3 d. (B) Balb/c mice treated with the mAbs indicated were given 2 × 10³ CFU Listeria and treated daily with either 0.3 ml PBS or an equal volume containing 5 μg rIL-18 as indicated. The bacterial burden per spleen was evaluated after 2 d. Each bar represents the mean CFU per group ± SD for ≥5 mice per group. Results were reproducible in greater than three experiments. Statistical analysis was performed using Dunnett's. *P < 0.05 versus isotype control plus PBS. **P < 0.05 versus isotype control plus rIL-18.

TNF contributes to the protective effects of IL-18. (A) Balb/c mice were injected with the mAbs indicated before infection with 2 × 10³ CFU Listeria and the bacterial burden per spleen was evaluated after 2 or 3 d. (B) Balb/c mice treated with the mAbs indicated were given 2 × 10³ CFU Listeria and treated daily with either 0.3 ml PBS or an equal volume containing 5 μg rIL-18 as indicated. The bacterial burden per spleen was evaluated after 2 d. Each bar represents the mean CFU per group ± SD for ≥5 mice per group. Results were reproducible in greater than three experiments. Statistical analysis was performed using Dunnett's. *P < 0.05 versus isotype control plus PBS. **P < 0.05 versus isotype control plus rIL-18.

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