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. 2001 Aug 6;194(3):321–330. doi: 10.1084/jem.194.3.321

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Influence of the C5 locus on the rapidity/severity of K/B×N serum-transferred arthritis. The results from the (B6 × NOD) F2 analysis of Fig. 4 are represented after segregating the mice into C5 ^b/n heterozygotes (left) or C5 ^b/b homozygotes (right); all C5^n/n mice are fully resistant to disease and are not represented. Within these two groups, mice of different genotypes at D1MIT33 are represented by different symbols. Note how the C5 locus alone has a major influence on severity, such that the effect of the D1MIT33 genotype, readily apparent in C5^b/n mice, is far less obvious in C5^b/b animals.