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. 2001 Aug 6;194(3):355–364. doi: 10.1084/jem.194.3.355

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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IL-18 KO mice secrete high levels of IL-4 and IL-13 and are resistant to chronic T. muris infection. (A) Worm burdens from T. muris–infected IL-18 KO (striped bar), IL-12p40 KO (white bar), and C57Bl/6 WT (black bar) mice were assessed at days 10, 18, and 35 p.i. MLN cells were removed at day 0 (naive) and day 18 p.i. and stimulated in vitro with T. muris Ag (B–D) or LPS (E and F). Supernatants were analyzed by sandwich ELISA for the presence of (B) IFN-γ, (C) IL-4, (D) IL-13, (E) IL-12p40, and (F) IL-18. Results represent the mean value of 5–7 mice per group ± SEM. *Significantly different from WT. P < 0.05. **Significantly different from other KO. P < 0.05. nd, not detectable.