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. 2001 Aug 6;194(3):355–364. doi: 10.1084/jem.194.3.355

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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In vitro treatment with exogenous rIL-18 inhibits Ag-induced IL-13 secretion in MLN cultures from T. muris–infected IL-12 and IFN-γ KO mice. MLN cells from day 18 T. muris–infected IL-12p40 KO mice (A) and IFN-γ KO mice (B) were stimulated with T. muris Ag plus indicated doses of rIL-18 in vitro and the supernatant analyzed for IL-13, IL-4, IL-5, IL-10, and IFN-γ secretion by sandwich ELISA. Results represent the mean value of 5–7 mice per group ± SEM. *Significantly different from cultures stimulated with T. muris Ag only. P < 0.05.

In vitro treatment with exogenous rIL-18 inhibits Ag-induced IL-13 secretion in MLN cultures from T. muris–infected IL-12 and IFN-γ KO mice. MLN cells from day 18 T. muris–infected IL-12p40 KO mice (A) and IFN-γ KO mice (B) were stimulated with T. muris Ag plus indicated doses of rIL-18 in vitro and the supernatant analyzed for IL-13, IL-4, IL-5, IL-10, and IFN-γ secretion by sandwich ELISA. Results represent the mean value of 5–7 mice per group ± SEM. *Significantly different from cultures stimulated with T. muris Ag only. P < 0.05.