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. 2001 Aug 20;194(4):507–518. doi: 10.1084/jem.194.4.507

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Attenuated development of T cells in zap-70 ^−/ − mice expressing ZAP-70(Y319F). Thymocytes (A) and splenocytes (B) isolated from ZAP-70(Y319F)⁺ zap-70 ^−/ − mice were analyzed for CD4 and CD8 (top) and CD3 (bottom) expression. Representative profiles of two independent transgenic lines (985 and 974) are shown. Average thymocyte number isolated for each genotype is represented in Table .