Table 1.
Cell Number and Subset Distribution of Thymocytes
| Percentage of cells within T cell subset | ||||||
|---|---|---|---|---|---|---|
| Genotype | Number of miceanalyzed | Cell number | CD4−CD8− | CD4+CD8+ | CD4+CD8− | CD4−CD8+ |
| n | × 10−6 | |||||
| Tg− zap-70 +/− | 35 | 330 ± 19 | 4.3 ± 0.3 | 81.2 ± 2.2 | 8.6 ± 0.4 | 3.6 ± 0.2 |
| wt ZAP-70+ zap-70 −/− | 10 | 311 ± 56 | 4.4 ± 0.5 | 80.8 ± 1.1 | 10.5 ± 0.5 | 4.2 ± 0.5 |
| ZAP-70(Y319F)+ zap-70 −/− (line 985) | 10 | 263 ± 16 | 6.0 ± 0.5 | 87.6 ±0.5 | 3.1 ± 0.2 | 3.0 ± 0.2 |
| ZAP-70(Y319F)+ zap-70 −/− (line 974) | 8 | 266 ± 40 | 5.2 ± 0.5 | 85.9 ± 0.8 | 5.7 ± 0.8 | 3.2 ± 0.2 |
| ZAP-70(Y315F)+ zap-70 −/− (line 1059) | 17 | 265 ± 34 | 3.7 ± 0.7 | 83.0 ± 0.9 | 8.6 ± 0.4 | 4.4 ± 0.3 |
| ZAP-70(Y315F)+ zap-70 −/− (line 1075) | 9 | 348 ± 45 | 3.7 ± 0.3 | 86.0 ±1.3 | 7.4 ± 0.8 | 3.1 ± 0.4 |