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IFN-γ causes both transcriptional induction and suppression. Transcriptional run-ons were performed with nuclei from macrophages that had been treated with 0 or 100 U/ml IFN-γ for 48 h. Fold-change results by microarray analysis are indicated. Genes were selected based on high signal intensity on microarrays. Plasmid DNA (pBR322) served as a control.
