Table 1.
Genes Regulated in Response to IFN-γ and Mtb in wt Macrophages: Examples with Potential Relevance to Tuberculosis
| Family | Gene product | Expression: fold-change in response to | ||
|---|---|---|---|---|
| IFN-γ | Mtb | IFN-γ plus Mtb | ||
| iNOS | iNOS | 28 | ns | 423 |
| GTPases | IGTP | 24 | 4.0 | 27 |
| Irg-47 | 7.1 | ns | 6.5 | |
| LRG-47 | 3.6 | 2.0 | 3.7 | |
| GBP2 | 127 | 5.5 | 146 | |
| Protease inhibitor | secretory leukocyte protease inhibitor | ns | 21 | 43 |
| Chemokines | MIG | 223 | ns | 432 |
| RANTES | 137 | 20 | 322 | |
| IP-10 | 32 | 5.7 | 83 | |
| KC | ns | ns | 20 | |
| JE | ns | 6.3 | 17 | |
| MIP2 | 0.5 | 12 | 12 | |
| MCP-5 prec | 5.7 | 5.1 | 8.8 | |
| MIP-1β | ns | 2.1 | 2.0 | |
| MIP-1α | ns | 2.0 | 2.0 | |
| C10-like chemokine | 0.16 | 1.9 | 0.27 | |
| platelet factor 4 prec | 0.04 | ns | 0.05 | |
| Chemokine receptors | CC CKR1 | 3.6 | 3.7 | 8.3 |
| putative β chemokine receptor (E01) | ns | ns | 7.1 | |
| β CKR-5 | 6.9 | ns | 4.5 | |
| CXCR4 | 0.22 | ns | 0.15 | |
CKR, chemokine receptor; LRG-47, large G protein–related protein of 47 kDa; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; ns, regulation not statistically significant.