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. 2001 Oct 15;194(8):1111–1122. doi: 10.1084/jem.194.8.1111

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Comparison of TREM-2-, LPS/TLR-, and FcR-mediated maturation pathways. Monocyte-derived DCs were stimulated with plastic-bound control F(ab′)₂ (black bars), F(ab′)₂ anti–TREM-2 (red bars), human IgG (blue bars), or LPS (green bars) in the presence of inhibitors for Erk (PD98059), p38/SAPK (SB203580), PTK (PP2), IκBα degradation (TPCK), or an equal volume of DMSO as a control. After 48 h, cell surface expression of CD86 (top left panel), MHC class II (middle left panel), CD40 (bottom left panel), CD83 (top right panel), ICAM-1 (middle right panel), or CCR7 (bottom right panel) was determined by flow cytometry. Data shown are representative of four independent experiments and display the mean and standard deviation of three independent samples.