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. 2001 Oct 15;194(8):1151–1164. doi: 10.1084/jem.194.8.1151

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Splenic B cells in mice with induced RAG-2 deficiency from birth are activated. RAG-2 ^fl/del, Mx-cre mice, and littermate controls were injected with type I IFN at birth. At the age of 8 wk, splenocytes were analyzed by FACS^® for the expression of activation markers as indicated. Shaded histograms represent controls and unshaded histograms the induced mutants. FSC, forward scatter.