Table 1.

Summary of TCR–pMHC Binding Constants and Peptide Sensitivity of T Cell Transfectants

	Binding to QL9/Ld				IL-2 sensitization dose (SD50) (nM)
2C TCR	ka	kd	KD	t1/2	QL9	Y5	E8	M5	p2Ca
	(M−1s−1) × 104	(s−1) × 10−4	nM	s
wt	0.6	200	3,000	35	0.9	0.3	6	2	2,000
m6 mutant	4.2	4.2	10	1,650	0.003	0.0008	0.8	0.01	40