Figure 5.
Self-specific CD4− CD8α+β−TCRαβ+ iIELs protect SCID.C57Bl/6 recipients of splenic CD4+CD45RBhiTCRαβ+ T cells from colitis. Pathology scores of individual male (□) and female (○) SCID.C57Bl/6 recipients of CD4−CD8α+β− iIELs expressing an HY/Db-specific transgenic TCRαβ, and splenic CD4+CD45RBhiTCRαβ+ T cells derived from male donors. Significant (P < 0.05) protection of male recipients was observed.