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. 2002 Jun 17;195(12):1533–1539. doi: 10.1084/jem.20020067

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — Characterization of T cells in young adult IL-7 TG mice. (A) T cell subset distribution and cell numbers in the thymus, LN, and spleen in IL-7 TG and LMs. Cells were triple-stained for CD4, CD8, CD44, or CD122 and analyzed by flow cytometry as described in Materials and Methods. Total numbers of thymocytes and indicated naive and memory phenotype CD4⁺ and CD8⁺ cells, combined from spleen and pooled LNs, IL-7 TG, and LMs are shown. Data are representative of >20 TG and LM mice. (B) Expression of CD44 and CD122 on gated LN CD4⁺ and CD8⁺ cells from IL-7 TG and LMs. (C) Randomly distributed CDR3 lengths of TCR-Vα chains expressed on CD8⁺ cells from IL-7 TG mice. CDR3 lengths on most Vα and all Vβ chains were determined on purified CD8⁺ cells from IL-7 TG and LM mice as described in Materials and Methods. Representative data for indicated Vα chains are shown; all analyzed chains were randomly distributed in both TG and LM cells.