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. 2002 Jun 17;195(12):1523–1532. doi: 10.1084/jem.20020066

Figure 4.

Figure 4.

Mice deficient in both IL-7 and IL-15 fail to support homeostatic proliferation of memory phenotype CD8+ cells but support efficient homeostatic proliferation of memory phenotype CD4+ cells. Small numbers (106) of sorted and CFSE-labeled B6.PL CD44hi T cells were transferred into irradiated B6, IL-7, IL-15, and combined IL-7 IL-15 mice; proliferation of donor cells was examined 7 d later. Shown are CFSE profiles of gated donor CD44hi CD4+ and CD44hi CD8+ cells in the LN. Similar results were obtained from two other experiments.