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. 2001 Dec 17;194(12):1875–1881. doi: 10.1084/jem.194.12.1875

Figure 1.

Figure 1.

FTY720 treatment reduces lymphocyte counts in CCR7−/− mice. Peripheral blood was taken before FTY720 administration and at indicated time points afterwards and analyzed by cell counting and flow cytometry. (A) CCR7−/− and wild-type mice were given FTY720 in drinking water (2 μg/ml; closed symbols) or water only (open symbols). Mean values of five animals each are represented and error bars indicate standard deviation. (B) CCR7−/− and wild type mice were given FTY720 orally once by gavage (6 μg/animal) and then in drinking water (2 μg/ml) or vehicle only for control animals. Mean values of four animals each are represented, and cell number is expressed as percentage of matching untreated control animals.