Figure 2.

FTY720 treatment increases homing of lymphocytes into PLNs and Peyer's patches in CCR7^−/− mice. CCR7^−/− and wild-type mice were given FTY720 (black bars) orally once by gavage (6 μg/animal) and then in drinking water (2 μg/ml) or vehicle only (white bars). After 18 h axilary LN (Ax.), brachial LN (Br.), and Peyer's patches (PP) were removed by dissection, and differential cell counts from single cell suspensions were determined by cell counting and flow cytometry. Mean values of six organs from three animals ± SD are shown.