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. 2002 Feb 4;195(3):359–365. doi: 10.1084/jem.20011576

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — Serum antibody response to (A) type 23F capsular polysaccharide (PS-23F) and (B and C) the recombinant NH₂-terminal fragment of PspA (PspA_31–189) from strain P833 used as the inoculum in experimental human carriage studies. PS-23F or PspA_31–189 was used in ELISAs to determine the PS-23F or PspA_31–189 specific IgG titers in uncolonized and colonized subjects (FS#) before (white bars) and at first time point that colonization was no longer detected (black bars). Values shown in panel A are ng/ml amounts of antibody and are from a representative experiment, in B are the mean antibody titers ±SEM for four independent experiments, and in C are a representative determination of the kinetics of the serum IgG response in colonized patients. ^ indicates point of inoculation. The final time point for each subject (FS#) was 2 wk after the last positive throat or nasal culture.

Figure 1. — Serum antibody response to (A) type 23F capsular polysaccharide (PS-23F) and (B and C) the recombinant NH₂-terminal fragment of PspA (PspA_31–189) from strain P833 used as the inoculum in experimental human carriage studies. PS-23F or PspA_31–189 was used in ELISAs to determine the PS-23F or PspA_31–189 specific IgG titers in uncolonized and colonized subjects (FS#) before (white bars) and at first time point that colonization was no longer detected (black bars). Values shown in panel A are ng/ml amounts of antibody and are from a representative experiment, in B are the mean antibody titers ±SEM for four independent experiments, and in C are a representative determination of the kinetics of the serum IgG response in colonized patients. ^ indicates point of inoculation. The final time point for each subject (FS#) was 2 wk after the last positive throat or nasal culture.