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. 2002 Feb 4;195(3):359–365. doi: 10.1084/jem.20011576

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — Nucleotide sequence and predicted translation product for an internal region of pneumococcal surface protein A (PspA). (A) database entry for a type 23F strain (GenBank/EMBL/DDBJ accession no. AF071811), (B) corresponding sequence for P833 used in nasal inoculations showing a frame-shift mutation within eight adenosines (shown by overlining) causing truncation of PspA as indicated, and (C) corresponding sequence from the last isolate obtained from subject FS1 which contains a compensatory two base pair deletion restoring expression of full-length PspA. Dash indicates a nucleotide deletion. The nucleotide and amino acid position is shown relative to the initiation codon.