Figure 1.

PARP^−/− mice are resistant to the toxic effects of MPTP. HPLC with electrochemical detection of DA and metabolites, HVA and DOPAC, 1 week after MPTP administration. All animals are on a pure genetic background of 129 SvEv. No differences in striatal DA or metabolite content was observed in WT or PARP^−/− animals after saline injection, and these values are graphically combined (n = 10). WT animals (n = 8) injected with MPTP (20 mg/kg ×4) have significant reductions in DA and metabolites compared with saline controls and PARP^−/− (n = 5). Two-way ANOVA, P < 0.004 for DA, HVA, and DOPAC. Student-Newman-Keuls post hoc analysis, ∗, P < 0.05 WT MPTP vs. saline, ^†, P < 0.05 WT MPTP vs. PARP^−/− MPTP.