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. 2002 Jan 21;195(2):161–169. doi: 10.1084/jem.20011171

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — Effect of anti-TRAIL mAb on outgrowth of subcutaneously inoculated fibrosarcoma cell lines. (A) Susceptibility of MCA-induced fibrosarcoma cell lines to TRAIL-mediated cytotoxicity. Cytotoxic activity of mTRAIL-transfected 2PK-3 (mTRAIL/2PK-3) and mock-transfected 2PK-3 cells against MCA-induced fibrosarcoma cell lines (MCA-III and MCA-IV) was tested by an 8 h ⁵¹Cr release assay. Data are represented as the mean ± SD of triplicate samples at an E/T ratio = 10. (B) The indicated number of MCA-III (white symbols) and MCA-IV (black symbols) cells were inoculated subcutaneously in the hind flank of wild-type B6 mice. Mice were administered intraperitoneally with anti-TRAIL mAb (circles) or isotype-matched control rat Ig (squares) every 5 d. Data are represented as the mean ± SD of five mice in each group.