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. 2002 Jan 21;195(2):161–169. doi: 10.1084/jem.20011171

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Copyright © 2002, The Rockefeller University Press

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Figure 6. — Effect of IFN-γ on susceptibility of MCA-induced fibrosarcoma cells to TRAIL-mediated cytotoxicity. MCA-induced fibrosarcoma cells from control Ig- or anti-TRAIL mAb-treated p53^+/− or wild-type mice, control Ig- or anti-ASGM1 Ab-treated wild-type mice, or IFN-γ–deficient mice were preincubated with (solid black bars) or without (gray bars) IFN-γ for 24 h. Then, their susceptibility to TRAIL-mediated cytotoxicity was determined as described in Fig. 2. Data are represented as the mean ± SD of triplicate samples at an E/T = 10. The cytotoxic activity of mock-transfected 2PK-3 cells against all tumor cells was <2% (data not shown).