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. 2002 Feb 18;195(4):517–528. doi: 10.1084/jem.20011672

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Impact of in vivo depletion of Ly6G/C⁺ cells on IFN-α/β production during MCMV versus LCMV infections. (A) Flow cytometry analysis of the percentages of CD8α⁺Ly6G/C⁺ cells within splenic DCs from mice uninfected, infected by MCMV or by LCMV, and untreated or injected with anti-Ly6G/C versus control antibody. (B) Titration of IFN-α (ELISA, black bars) and IFN-α/β (bioassay, gray bars) in the sera from the same mice. The sera of the mice injected with the antibodies but uninfected were negative for IFN-α/β (data not shown). The data shown are representative of three independent experiments in 129 mice for MCMV and one for LCMV. Similar results were obtained in C57BL6 mice (2 and 1 experiments, respectively).