Table I.
Impact of T and NK Cell Functions on IL-12p40 and IFN-α Production in Mice Infected with MCMV or LCMV
| Treatmenta
|
Serum cytokine concentration (pg/ml)c
|
||||
|---|---|---|---|---|---|
| Strain | Virus | PFUs | n b | IL-12p40 | IFN-α |
| C57BL/6 | MCMV | 5 × 104 | 7 | 1.474 ± 279 | 24,297 ± 5,742 |
| 129 | MCMV | 5 × 104 | 2 | 4,314 ± 313 | 177,034 ± 28,607 |
| E26 | MCMV | 5 × 104 | 3 | 3,000 ± 312 | 11,347 ± 350 |
| 129 | MCMV | 1 × 104 | 17 | 2,743 ± 1,261 | 361,986 ± 110,150 |
| E26 | MCMV | 1 × 104 | 8 | 2,023 ± 409 | 89,316 ± 34,985 |
| 129 RAG-2M | MCMV | 1 × 104 | 7 | 1,010 ± 301 | 98,483 ± 55,425 |
| 129 | LCMV | 2 × 104 | 12 | BLDd | 28,238 ± 18,742 |
| C57BL/6 | LCMV | 2 × 104 | 6 | BLD | 23,934 ± 7,763 |
| E26 | LCMV | 2 × 104 | 3 | BLD | 30,038 ± 4,507 |
a
Mice were infected intraperitoneally for 1.5 d for MCMV or 2 d for LCMV with the indicated viral dose of PFUs.
b
Number of mice studied.
c
Mean ± standard error. Cytokine titers were measured by ELISA as described in Materials and Methods.
d
BLD, below level of detection. Serum cytokine levels were <20 pg/ml in uninfected mice (data not shown).