Table II.

Impact of IFN-α/β Functions on IL-12 Production by DC Subsets^f

Stain or treatment	n a	IL-12p40 (pg/ml)		Percentage of IL-12+ cells within DC subsetsb
		Serab	DC CMc	CD11c+	CD8α1	CD11b+
IFN-α/βR+/+	4	2,821 ± 288	2,222	13.5 ± 0.7	28.8 ± 0.8	5.2 ± 0.5
IFN-α/βR−/−	4	7,975 ± 1,034d	8,285	20.4 ± 2.6e	39.9 ± 1.8d	14.3 ± 2.4d
STAT-1+/+	3	2,211 ± 508	ND	6.7 ± 1.9	24.4 ± 3.7	5.5 ± 0.7
STAT-1−/−	3	4,060 ± 152	ND	10.5 ± 1.1g	27.4 ± 1.5g	13.7 ± 1.9e
Control Ab	4	2,121 ± 498	13,064	3.8 ± 0.7	16.1 ± 3.0	2.8 ± 1.1
Anti-Ly6G/C	4	2,878 ± 226g	6,240	5.3 ± 0.6h	8.1 ± 1.3e	9.2 ± 1.1d

Mice were infected intraperitoneally for 1.5 d with 10⁴ PFUs MCMV.

Data from IFN-α/βR^+/+ versus IFN-α/βR^−/− are from one representative experiment out of three.

^aNumber of mice per group.

^bMean ± standard error.

^c24-h CM from enriched DCs.

^d P < 0.001.

^e P < 0.005.

^f P < 0.01.

^gNS.

^h P < 0.05.