Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2002 Feb 18;195(4):507–516. doi: 10.1084/jem.20011666

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2002, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — VSV and UV-HSV injection, but not poly(I:C) stimulation, leads to high-level production of type I IFN by cells located in the marginal zone of the spleen. (a) WT mice were VSV infected and after 9 h spleens were analyzed immunohistochemically with a polyclonal serum against type I IFN (pAb, top two panels) or with an IFN-α–specific mAb (mAb, bottom two panels). (b) A higher magnification of the marginal zone area of the bottom right panel in (a) stained with mAb is shown. (c) WT and IFNAR^−/− mice were VSV, poly (I:C), or UV-HSV injected. After 9 h and 6 h after UV-HSV stimulation, spleens were analyzed immunohistochemically with a polyclonal serum against type I IFN. Sections in (a–c) were counterstained with hemalum (blue) to visualize lymph follicles. (d) In situ hybridization of IRF-7 mRNA (blue) was performed on paraffin sections of spleen from WT and IFNAR^−/− mice prepared 9 h after VSV infection.