TABLE 1.
Drug resistance phenotype of the tbat1-null mutant compared to the parental wild-type strain
| Drug | IC50a (ng/ml)
|
Resistance factor | |
|---|---|---|---|
| Wild type | TbAT1−/− mutant | ||
| Melarsoprol | 21 ± 3 | 49 ± 9 | 2.3 |
| Melarsen oxide | 3.7 ± 0.1 | 11 ± 0.1 | 3.0 |
| Cymelarsan | 6.1 ± 1 | 12 ± 3 | 2.0 |
| Pentamidine | 5.1 ± 2 | 12 ± 3 | 2.4 |
| Diminazene | 120 ± 30 | 2,300 ± 500 | 19 |
| Propamidine | 67 ± 7 | 750 ± 20 | 11 |
| Stilbamidine | 680 ± 70 | 5,000 ± 1,300 | 7.4 |
a
IC50 were determined in vitro by using the Alamar Blue assay. Values are means from at least three independent experiments ± standard errors.