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. 1999 May 17;189(10):1649–1658. doi: 10.1084/jem.189.10.1649

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Modulation of FcεRI-dependent release by Syt II. Passively sensitized control (○), Syt II⁺ (•), and Syt II⁻ (▪) cells were incubated for 30 min at 37°C with the indicated concentrations of the corresponding antigen, DNP-BSA. The extent of release is presented as percentage of total β-hexosaminidase activity. The results presented are of a representative experiment, that included three independent clones, stably transfected with the empty pcDNA3 vector, three independent clones stably transfected with the pcDNA3-Syt II recombinant vector and three independent clones stably transfected with pcDNA3-Syt II in the antisense orientation. The data points are means ± SEM of six determinations. Similar results were obtained on five occasions. Inset: β-hexosaminidase release of individual clones (1–3 stably transfected with the empty pcDNA3 vector and 4–6 stably transfected with pcDNA3-Syt II in the antisense orientation) at a representative concentration of antigen (10 ng/ml DNP-BSA).