Figure 4.
Migration of activated CD8 T cells to intestinal mucosa is dependent on β7 integrins. Equal numbers of LN cells from OT-I (Ly5.1+5.2+) and OT-I-β7−/− (Ly5.1+5.2−) mice were transferred to normal C57BL/6-Ly5.1−5.2+ mice. 48 h later, mice were infected with VSV-ova or not. 3 d after infection, mice were killed and lymphocyte populations were isolated and examined for the presence of donor populations by detection of Ly5.1/Ly5.2 expression by fluorescence flow cytometry.