Figure 7.

αEβ7 integrin is not required for entry of activated CD8 T cells into the intestinal mucosa. Equal numbers of LN cells from OT-I (Ly5.1⁺5.2⁺) and OT-I-αE^−/− (Ly5.1⁺5.2⁻) mice were transferred to normal C57BL/6-Ly5.1⁻5.2⁺ mice. 48 h later, mice were infected with VSV-ova or not (naive). 3 d later, IEL and LP cells were isolated and analyzed for the presence of transferred cells by flow cytometric detection of  Ly5.1 and Ly5.2 expression.