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. 2002 Apr 15;195(8):959–971. doi: 10.1084/jem.20011948

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — Anti-B7 blockade in the perinatal period (from E16 to day 10 after birth) significantly reduced the efficacy of T cell clonal deletion, analyzed on day 15 after birth. (a) Anti-B7 mAb increased the total number of thymocytes in transgenic mice expressing both the T cell receptor and its specific antigen. Data shown are summarized from three independent experiments. Each point represents one double transgenic mouse. (b) Thymocyte composition in TCR single transgenic (P1CTL⁺/P1A⁻) or TCR P1A double transgenic (P1ACTL⁺/P1A⁺) mice. Transgenic thymocytes were analyzed by three-color flow cytometry using anti-Vα8, anti-CD4, and anti-CD8 mAbs. The number of thymocytes is given at the bottom of each panel, and the percentage of the Vα8⁺ cells is provided in the parentheses. Data shown are profiles of gated Vα8⁺ T cells and are representative of three independent experiments. (c) The subset distribution of gated Vα8⁻ T cells from either anti-B7 or control Ig-treated double transgenic mice. The percentage of the gated population is presented at the bottom of each panel.