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. 2002 Apr 15;195(8):959–971. doi: 10.1084/jem.20011948

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Anti-B7 mAb treatment increases the amount of mature CD4⁻CD8⁺Vα8⁺T cells in the spleen. Top panels show the expression of the CD8 coreceptor, whereas the lower panels show the expression of CD44 activation markers. Among the P1A and P1CTL double transgenic mice, anti–B7- and the control Ig-treated groups have a similar number of Vα8⁺ transgenic T cells. However, the number of Vα8⁺CD8⁺ mature T cells is increased by 2.5-fold in the anti–B7-treated group. Data shown are the contour plots of gated Vα8⁺ T cells and are representative of three independent experiments.