Figure 1.
After LCMV infection, the percentage of virus specific splenic T cells is higher in JNK2−/−, but similar in JNK1−/− and JNK+/+ mice. JNK1−/−, JNK2−/−, and JNK+/+ animals were injected intraperitoneally with LCMV ARM 2 × 105 PFU. 7 (D7) or 8 (D8) d after infection, spleens were processed and stimulated for 5 h in vitro with virus specific peptide GP aa 33–41. Cells were then stained for CD8 and intra-cellular IFN-γ. Values written in the dot plots indicate the percentage of CD8+ T cells positive for IFN-γ.