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. 2002 Apr 1;195(7):801–810. doi: 10.1084/jem.20011481

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — During the acute infection, the number of splenic CD8⁺ T cells CD44^hi is lower in JNK1^−/− mice than in JNK2^−/− and JNK^+/+ mice, and a greater proportion of these cells from JNK1^−/− undergo apoptosis. JNK1^−/−, JNK2^−/−, and JNK^+/+ animals were injected intraperitoneally with LCMV ARM 2 × 10⁵ PFU. 8 d after infection, spleen were processed to make single cell suspension devoted of red blood cells and stained directly for surface markers: CD4, CD8, and CD44 then annexin-V and 7AA-D were added. Data represent average values obtained from four animals per group and are representative of two independent experiments. The percentage of CD8⁺ or CD4⁺ that were CD44^hi are shown in the left, that were annexin V⁺ cells among the CD8CD44^hi or CD4CD44^hi on the right. (A) CD8⁺ T cells. (B) CD4⁺ T cells. *P < 0.05 compared with JNK^+/+.

Figure 4. — During the acute infection, the number of splenic CD8⁺ T cells CD44^hi is lower in JNK1^−/− mice than in JNK2^−/− and JNK^+/+ mice, and a greater proportion of these cells from JNK1^−/− undergo apoptosis. JNK1^−/−, JNK2^−/−, and JNK^+/+ animals were injected intraperitoneally with LCMV ARM 2 × 10⁵ PFU. 8 d after infection, spleen were processed to make single cell suspension devoted of red blood cells and stained directly for surface markers: CD4, CD8, and CD44 then annexin-V and 7AA-D were added. Data represent average values obtained from four animals per group and are representative of two independent experiments. The percentage of CD8⁺ or CD4⁺ that were CD44^hi are shown in the left, that were annexin V⁺ cells among the CD8CD44^hi or CD4CD44^hi on the right. (A) CD8⁺ T cells. (B) CD4⁺ T cells. *P < 0.05 compared with JNK^+/+.