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. 2002 Apr 1;195(7):801–810. doi: 10.1084/jem.20011481

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — The number of splenic virus specific CD8⁺ T cells and CD4⁺ T cells is lower in JNK1^−/− mice than in either JNK2^−/− or JNK^+/+ mice during the acute response but not during the secondary response. JNK1^−/−, JNK2^−/−, and JNK^+/+ mice were injected intraperitoneally with LCMV ARM 2 × 10⁵ PFU. Spleens were harvested at day 7, 8, 14, or 60 postinfection or 4 d after a challenge with Cl-13 (10⁶ PFU intravenously) in memory animals. Spleen cells were stimulated for 5 h in vitro with virus specific peptides GP aa 33–41 or NP aa 396–404, then stained for CD8 and intracellular IFN-γ. The number of virus specific T cells was calculated from the number of total spleen cells obtained per animal. Data represent average values obtained from three animals per group and are representative of two independent experiments. *P < 0.05, #P = 0.057 compared with JNK^+/+.

Figure 5. — The number of splenic virus specific CD8⁺ T cells and CD4⁺ T cells is lower in JNK1^−/− mice than in either JNK2^−/− or JNK^+/+ mice during the acute response but not during the secondary response. JNK1^−/−, JNK2^−/−, and JNK^+/+ mice were injected intraperitoneally with LCMV ARM 2 × 10⁵ PFU. Spleens were harvested at day 7, 8, 14, or 60 postinfection or 4 d after a challenge with Cl-13 (10⁶ PFU intravenously) in memory animals. Spleen cells were stimulated for 5 h in vitro with virus specific peptides GP aa 33–41 or NP aa 396–404, then stained for CD8 and intracellular IFN-γ. The number of virus specific T cells was calculated from the number of total spleen cells obtained per animal. Data represent average values obtained from three animals per group and are representative of two independent experiments. *P < 0.05, #P = 0.057 compared with JNK^+/+.