Table I.
Primary CTL Activity and Function Are Normal in JNK1−/− and JNK2−/− Animals
| Specific 51Cr releasea | ||||
|---|---|---|---|---|
| Group | Effector/ target ratio |
H-2b | H-2d | Clearance of LCMV from serab |
| JNK1−/− | 50:1 | 35 ± 4 | <1 | 4/4 |
| 25:1 | 23 ± 3 | <1 | ||
| 12:1 | 14 ± 4 | <1 | ||
| JNK2−/− | 50:1 | 40 ± 6 | <1 | 4/4 |
| 25:1 | 40 ± 2 | <1 | ||
| 12:1 | 22 ± 5 | <1 | ||
| JNK+/+ | 50:1 | 27 ± 4 | <1 | 4/4 |
| 25:1 | 22 ± 3 | <1 | ||
| 12:1 | 14 ± 2 | <1 | ||
a
Average of four mice per group, no statistical difference between groups.
b
To evaluate clearance of infectious virus, sera were harvested 8 d after LCMV inoculation while 2-3 d after inoculation with LCMV-ARM 2 × 105 PFU intraperitoneal viral titers range at 3 logs of infectious virus/ml of sera (references 23 and 34), at day 8 no detectable infectious virus was observed in any of the sera by plaque assay (reference 32).