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. 2002 Mar 18;195(6):695–704. doi: 10.1084/jem.20011603

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — IL-10 is required for the generation of IL-10–producing CD8 T cells and mediates the poor cytolytic activity and secondary hyporesponsiveness of DC2-primed CD8 T cells. (A) Cytokine profile of CD8 T cells primed for 6 d with DC1, DC2, or DC2 plus neutralizing anti–IL-10 (10 μg/ml). (B) CD8 T cells primed with DC1 (•), DC2 (○), or DC2 plus anti–IL-10 (□) were tested for the ability to lyse allogeneic B cells in a 5-h Cr-release assay. Specific lysis of autologous B cells remained below 15% in all conditions (unpublished data). (C) Secondary proliferation of CD8 T cells primed with DC1, DC2, or DC2 plus anti–IL-10 after a 3-d restimulation with DC2. Equivalent results were obtained by restimulation with DC1 (unpublished data). Results are representative of three independent experiments.

Figure 5. — IL-10 is required for the generation of IL-10–producing CD8 T cells and mediates the poor cytolytic activity and secondary hyporesponsiveness of DC2-primed CD8 T cells. (A) Cytokine profile of CD8 T cells primed for 6 d with DC1, DC2, or DC2 plus neutralizing anti–IL-10 (10 μg/ml). (B) CD8 T cells primed with DC1 (•), DC2 (○), or DC2 plus anti–IL-10 (□) were tested for the ability to lyse allogeneic B cells in a 5-h Cr-release assay. Specific lysis of autologous B cells remained below 15% in all conditions (unpublished data). (C) Secondary proliferation of CD8 T cells primed with DC1, DC2, or DC2 plus anti–IL-10 after a 3-d restimulation with DC2. Equivalent results were obtained by restimulation with DC1 (unpublished data). Results are representative of three independent experiments.