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. 2002 Mar 18;195(6):771–780. doi: 10.1084/jem.20011140

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — Hox11-null and splenectomized mice do not respond to vaccination with streptococcal polysaccharides. Pneumovax^® 23 was injected subcutaneously, intramuscularly, intraperitoneally, or intravenously into either (A) C57BL/6 and Hox11-null mice or (B) sham-operated and splenectomized mice. Specific IgM antibodies in sera were measured by ELISA before and 6 d after immunization. The optical density (OD₄₀₅) measured with a 1:80 serum dilution is shown. Each data point indicates the relative antibody level of a single mouse.

Figure 5. — Hox11-null and splenectomized mice do not respond to vaccination with streptococcal polysaccharides. Pneumovax^® 23 was injected subcutaneously, intramuscularly, intraperitoneally, or intravenously into either (A) C57BL/6 and Hox11-null mice or (B) sham-operated and splenectomized mice. Specific IgM antibodies in sera were measured by ELISA before and 6 d after immunization. The optical density (OD₄₀₅) measured with a 1:80 serum dilution is shown. Each data point indicates the relative antibody level of a single mouse.